SARMs abbreviation is “Selective androgen receptor modulator”. By the same principle as SERMs – selective modulators of estrogen receptors, which include well-known clomiphene and tamoxifen, SARMs are able to join the receptors of sex hormones, only not female, but male androgens and interact with them. But without the same structure as anabolic steroids, SARMs do not respond to enzymes that convert testosterone into other compounds that have undesirable effects.
Creating this class of drugs, scientists expected to reduce the adverse effects of testosterone on the prostate. As is customary, first of all, any substances and compounds investigate the animals; in case of receiving positive effects and making sure of the safety of their reception, conduct clinical studies in humans, and then run into production. Often, only positive results in experiments on rats are enough to get the drug in the field of view of “chemical” athletes and they began to independently test it on themselves.
Approximately the same situation has developed with SARMs – as soon as saying that their reception leads to the growth of muscle mass, they immediately found themselves in the hands of bodybuilders. One of the first, despite the ambiguous findings of research, better known in the world of sports. SARMs drugs were already in full swing in bosspeptides.com before there was official confirmation that SARMs really contributes to the increase in muscle mass in humans and is relatively safe to use. However, in the sphere of sports and the threat of anti-doping controls SARMs is not risky, since its metabolites are determined for three months or more – depending on the dose and individual characteristics of metabolism in the athlete.
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According to study “Selective androgen receptor modulator” improves muscle mass and physical functions in healthy elderly men and women in postmenopausal women. In this study, the results of taking SARMs, attributed to the statistically significant by scientists: the 12-week course of oral intake of 3 mg of the drug leads to a gain of dry muscle mass of 1.4 kg and a reduction in fat mass of 300 grams, without any physical exertion. Lower dosages of the substance led to less pronounced results. The official conclusion of the researchers was as follows: SARMs showed a dose-dependent improvement in overall muscle mass and physical functions, well tolerated. SARMs may be useful for the prevention and/or treatment of muscle catabolism associated with cancer and other chronic diseases. Maybe 1.4 kg of muscle mass in 12 weeks is not so much, but it is officially received and fixed result.
At present, pharmaceutical companies have several types of SARMs, for which the first stages of clinical research in humans have been successfully completed and that may soon appear in legal sales, and until then, the practice of their application for sporting purposes is likely to be formed, however, in the present moment, even based on a small amount of the above information, you can get an idea of the dosage, duration of administration and side effects.
At the moment, no selective androgen receptor modulator is truly selective. They show only a higher anabolic index, while the ratio of anabolic to androgenic activity is 3:1 to 10:1 (testosterone ratio is 1:1)
Virtually all selective androgen receptor modulators are available in the form of tablets and do not cause damage to the liver.
This is the optimal choice for women, because they have minimal impact on libido, sexual signs, blood cholesterol level, liver, etc.